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How long does Zoloft typically Stay in Your System?

Like any other medication, some patients have good experiences with FDA-approved Zoloft, while others face issues. This can lead some to stop taking it. But before doing that, it’s worth asking, “How long does Zoloft stay in your system?

Withdrawal from Zoloft (sertraline) can be challenging without medical support, so it’s crucial to consult your doctor first. This article explores what Zoloft is, its side effects,  how long does zoloft stays in your system, and treatments. Read on!

What is Zoloft (Sertraline)?

Zoloft or Sertraline, an FDA-approved selective serotonin reuptake inhibitor (SSRI), is prescribed to address a range of conditions, including obsessive-compulsive disorder, major depressive disorder, panic attacks, premenstrual dysphoric disorder, and social anxiety disorder.

By increasing serotonin levels in the body, Sertraline helps alleviate symptoms associated with these disorders, offering relief and improving overall well-being.

Regarding “How long does Zoloft stay in your system?” it’s important to note that the duration can vary depending on factors such as dosage, individual metabolism, and other medications being taken concurrently. Generally, Zoloft has a half-life of around 24 to 26 hours, meaning it takes roughly a day for half of the drug to be eliminated from the body.

Side Effects of Zoloft (Serotine)

Zoloft (Sertraline) commonly results in the following side effects:

  • Nausea
  • Changes in sleep patterns
  • Excessive sweating
  • Agitation
  • Fatigue
  • Risk of serotonin syndrome

Additionally, it shares side effects typical of other antidepressants, which are rare yet severe. It includes:

  • Suicidal thoughts
  • Dangerous impulses
  • Violent behavior
  • Comatose states
  • Respiratory problems
  • Swelling

If you experience severe or unusual symptoms, seek immediate medical attention and inform your healthcare provider.

How Long Does Zoloft Last in the Body?

Drug testing is employed to address the query, “How long does Zoloft stay in your system?” The duration for Zoloft to exit the body can vary among patients and is linked with the drug’s half-life.

However, detection times vary significantly based on the type of test conducted—whether it’s urine, saliva, blood, or hair.

● Zoloft in Urine Tests

Zoloft (Sertraline) can be detected for a maximum of nine days in a urine test.

● Zoloft in Hair Follicle Tests

Prescription drugs such as Zoloft (Sertraline) can persist for as long as 90 days in hair follicles. Among all testing methods, traces of the drug linger the longest in this type of test.

● Zoloft in Saliva Tests

Unlike other medications, Zoloft (Sertraline) remains detectable in saliva for two days.

● Zoloft Detection in Blood Tests

Zoloft (Sertraline) can be identified in the bloodstream for up to 5 days after the last usage.

Determining Factors on How Long Zoloft Stays in Your System

When asking, “How long does Zoloft stay in your system?” it’s important to recognize that responses to substances like Psilocybin and patients vary due to each medication’s unique chemical composition.

Sertraline’s duration in the body can differ significantly from other substances and may significantly affect a person’s recovery. Here are key factors to consider:

Dosage and frequency: Zoloft’s effectiveness varies individually. However, excessive doses taken regularly can lead to tolerance and exacerbate addiction issues.

● Physiological Factors

Each person’s body reacts differently to the drug, influenced by factors such as weight, age, and genetics.

● Mental Health Disorders

Coexisting conditions like panic disorder or depression can prolong Sertraline’s presence in the system, especially when coupled with addiction.

● Drug Half-life

Zoloft has a half-life of approximately 22 to 35 hours, meaning half of the drug is eliminated from the body within this timeframe.

● Renal & Hepatic Function

Efficient kidney and liver function are crucial for processing substances like Zoloft. Poor functioning in these organs can hinder the drug’s metabolism and elimination.

What Happens When You Stop Taking Zoloft?

When you’re tapering off Sertraline/Zoloft as part of a medication or addiction treatment plan, it can affect people in different ways. Withdrawal symptoms can vary from mild to severe.

Some common withdrawal symptoms include:

  • Trouble sleeping
  • Feeling unsteady or off-balance
  • Changes in hearing or vision
  • Feeling anxious
  • Sweating more than usual
  • Tingling sensations
  • Increased sensitivity
  • Muscle aches
  • Headaches

If someone starts having thoughts of self-harm, feelings of depression, or extreme mood swings during this process, they must reach out to a healthcare professional right away.

About Zoloft Misuse and Addiction Treatment

When it comes to addiction to prescribed antidepressants like Sertraline (Zoloft), three main factors play a significant role: psychological, emotional, and physical.

Sertraline addiction often stems from psychological, emotional, and physical factors, such as seeking confidence boosts, coping with stress and trauma, or craving the feel-good effects of the medication. Treatment options include rehab programs, behavioral therapy, and group sessions, providing support and addressing underlying issues.

How To Get Help from Zoloft Addiction?

Zoloft addiction treatment typically involves a tailored approach addressing both physical and psychological aspects. When considering “How long does Zoloft stay in your system?” it’s important to note that individual factors such as dosage, metabolism, and concurrent medications can influence its duration in the body, typically ranging from several days to a few weeks for full clearance. Common methods include:

1. Medical Detoxification

Safely tapering off Zoloft under medical supervision to manage withdrawal symptoms.

2. Behavioral Therapies

Such as cognitive behavioral therapy (CBT), which identifies triggers and develops coping strategies.

3. Support Groups

Participation can provide peer support and a sense of community.

4. Medication Management

Prescription medication may be used to alleviate specific symptoms or co-occurring mental health conditions.

5. Dual Diagnosis Treatment

Addressing any co-occurring mental health disorders alongside Zoloft addiction.

6. Aftercare Support

It includes creating and implementing a structured plan that includes ongoing therapy and support group participation to prevent relapse.


1. How long is Zoloft in your system after you stop taking it?

Drug half-life for Zoloft – Half of Zoloft can be expelled from a person’s body for roughly 22 to 35 hours.

2. Can you go back to normal after Zoloft?

The brain can gradually revert to its pre-medication state, but this process and outcomes vary widely. While some may return to their previous mental state, others might experience lasting changes or improvements.

3. Does Zoloft wear off over time?

It is relatively common for antidepressants to wear off over time. If this happens, a person’s doctor can increase their dose or change medication.

4. Is 25mg of Zoloft enough for anxiety?

For panic disorder, posttraumatic stress disorder, or social anxiety disorder, Adults typically start with 25 milligrams (mg) once daily, either in the morning or evening. Your doctor may adjust the dose as necessary.

5. Does anxiety come back after stopping Zoloft?

Discontinuation symptoms like anxiety and depression can occur. If they resurface, it might indicate a relapse, warranting ongoing treatment.


If you’re wondering, “How long does Zoloft stay in your system?” you must consider Zoloft’s half-life. A drug’s half-life refers to the amount of time it takes half of the drug to leave a person’s system. Zoloft has a half-life of 24 to 26 hours, meaning it takes about a day for half of it to leave the body. On another day, it decreases to 25%. In urine, Zoloft can stick around for roughly nine days.

Additionally, how long does Zoloft stays in your system varies based on factors like dose, weight, age, and metabolism. Taking a higher dose than prescribed or more often than directed can affect how long it stays in your system. It’s always recommended to consult your healthcare provider when taking any antidepressant.

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