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Is Trazodone a Controlled Substance: Facts & Uses

Nearly 26 million people in the US are prescribed trazodone, but the common question lingers, “Is trazodone a controlled substance?” Trazodone, available as Desyrel, Oleptro, and others, is FDA-approved for major depressive disorder. While depression and insomnia feed off each other and make life feel joyless, trazodone might offer initial relief. However, its long-term effects and potential for abuse could outweigh the benefits. Despite this, the  U.S. Food and Drug Administration (FDA) indicates that trazodone is not likely to lead to addiction or abuse. 

Trazodone seems to be discussed more now than before. While some medications have always been expected, they were less talked about due to the stigma surrounding their use. In an episode of HealingUS podcast, Michael’s early life in Brooklyn was deeply influenced by music, which fueled his passion for the industry. As an A&R executive, he made significant discoveries, including Metallica, and worked with stars like Cindy Lauper. Despite his impressive career, he encountered challenges with addiction and found medicines and holistic therapies that led him to his journey of recovery. Listen today for inspiration!

If you’re prescribed trazodone to treat a mental health condition, you might be wondering, “Is trazodone a controlled substance? In this blog, we’ll explain how it works, what conditions it can treat, potential side effects, overdose, and how it’s used in addiction treatment.

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What is Trazodone?

Trazodone is a medication used to treat major depressive disorder by increasing serotonin levels in the brain. Classified as a serotonin antagonist and reuptake inhibitor (SARI), the FDA approves it for the treatment of major depressive disorder. It is also commonly prescribed off-label for anxiety and insomnia.

Patients usually take trazodone once or twice a day, often with one dose before bed, to help with depression-related insomnia. If you take it twice daily, be aware of how it affects you, especially if it makes you tired.

It’s crucial to take trazodone precisely as prescribed and not stop it suddenly, as this can worsen depression or anxiety. Being consistent with the medication helps ensure the best results.

Is Trazodone a Controlled Substance?

While prescribed trazodone, you must be wondering, “Is Trazodone a Controlled Substance?” To answer this, Trazodone is not a narcotic or a controlled substance. Clinical trials of trazodone did not show any signs of drug-seeking behavior. 

Controlled substances are prescription drugs regulated due to their potential for abuse and dependence, as well as certain illegal drugs. These drugs are categorized into different schedules based on their medical use and abuse potential. Schedule I drugs have no medical use and the highest potential for abuse, while Schedules II, III, IV, and V have recognized medical uses and progressively lower potential for abuse. Schedule V drugs have accepted medical uses with the lowest potential for abuse.

However, Trazodone is not classified as a controlled substance because studies have not shown that people who take it are likely to abuse the drug or exhibit drug-seeking behavior. However, the potential for abuse and dependence on trazodone, especially with off-label use, has not been thoroughly researched.  

Another common drug for treating behavioral and mental health conditions is Xanax. Before you choose a medicine to treat your condition, it’s better to know their similarities and differences.

It’s crucial to take trazodone precisely as prescribed to minimize any risk of misuse. While trazodone may not cause addiction, studies show that there is a risk of physical dependence and withdrawal symptoms if the drug is stopped suddenly. It has a low potential for abuse and may cause mild physical dependence, similar to other antidepressants.

Trazodone Dosage

Trazodone dosages can vary depending on the patient and the condition being treated. It’s important to follow your doctor’s instructions or the directions on the label.

  • Average Dose for oral Trazodone150 mg daily, divided into smaller doses. Do not exceed 400 mg per day.
  • Extended-release Version: 150 mg per day in a single dose. Do not exceed 375 mg per day.
  • Off-label Use: There is no established dosage, but it’s usually lower than the dose for treating depression.

To optimize the drug dosage, it’s beneficial to know the half-time of the drug and how long does Trazodone stay in your system.

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Side Effects of Trazodone

According to the National Library of Medicine, some common side effects of Trazodone are:

  • Nausea and vomiting
  • Dizziness
  • Drowsiness
  • High blood pressure
  • Dry mouth

These usually aren’t serious, but let your doctor know if they don’t go away or bother you.

If not treated promptly, these side effects can take an evil turn. Some of the severe side effects of Trazodone include:

  • Allergic Reactions

Rash, itching, swelling of face, lips, tongue, or throat

  • Unusual Bleeding or Bruising

Bloody stools, dark urine, vomiting blood, small red spots on skin

  • Heart Issues

Irregular heartbeat, dizziness, chest pain, trouble breathing

  • Low Blood Pressure

Dizziness, fainting, blurred vision

  • Low Sodium

Muscle weakness, headache, confusion

  • Painful or Prolonged Erection (lasting more than 4 hours)

This can be a severe condition called priapism and needs immediate medical attention to prevent permanent damage.

  • Serotonin Syndrome

Irritability, confusion, fast heartbeat, muscle stiffness, high fever, seizures

  • Eye Problems

Sudden pain, blurred vision, seeing halos, vision loss

  • Mood Changes

Thoughts of suicide, worsening depression

Trazodone Drug Interaction

Taking trazodone with other serotonin-affecting medications (like dextromethorphan, tricyclic antidepressants, tryptophan, 5-HTP, or buspirone) can lead to serotonin syndrome. 

People with heart issues or those on medications that affect heart rhythm are at higher risk for irregular heartbeats.

How is Trazodone used in Addiction Treatment?

Trazodone is used for more than just depression and anxiety. It also has roles in treating addiction and co-occurring disorders involving substance use and mood disorders.

  • Co-occurring disorders

Depression or anxiety can lead to substance use as a way to cope. Treating these symptoms with trazodone may help prevent relapse.

  • Insomnia

Trazodone can treat insomnia, which is common during drug withdrawal and early addiction treatment. It’s often considered a safer option than other insomnia medications like benzodiazepines and hypnotics.

  • Not a standalone treatment

Trazodone is not used alone for addiction treatment. It’s usually combined with other therapies, such as group therapy, behavioral therapies, and support groups, to manage symptoms.

FAQs

Q: Is trazodone a controlled substance?  

A: No, Trazodone is not a controlled substance, meaning the risk for dependence and misuse is low. It’s not commonly used for depression due to its soothing qualities.

Q: Is trazodone a narcotic for sleep?  

A: Trazodone, initially an antidepressant, is now used as a sleep aid due to its soothing effects. However, it doesn’t address the cause of sleep problems and has serious side effects.

Q: What class of drug is trazodone?  

A: Trazodone is a serotonin-antagonist-and-reuptake-inhibitor used mainly for major depressive disorder, either alone or in combination with other treatments.

Q: What is the most significant side effect of trazodone?  

A: Serious side effects include yellowing of the eyes or skin, constipation, difficulty urinating, and unusual or unexplained bruising.

Q: Is trazodone a heavy sedative?  

A: Trazodone has mild sedating effects and is more commonly used as a sleep aid than as an antidepressant.

How can Relevance Recovery help you?

Whether you or a loved one have been using trazodone for a while, there’s no need to worry. We believe everyone should have access to quality care. Hence, at Relevance, our goal is to provide comprehensive and effective care that addresses the complex and delicate nature of mental health and substance use disorder. Ultimately, understanding the benefits and risks will help you make the best choice for your health and well-being.

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